SOX2 expression associates with stem cell state in human ovarian carcinoma Running title: SOX2 in ovarian carcinoma stem cells
نویسندگان
چکیده
Department of Internal Medicine II, University of Tuebingen, Tuebingen, Germany; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner SiemensFoundation, University of Tuebingen, Tuebingen, Germany; Institute of Pathology, University of Tuebingen, Tuebingen, Germany; Interfaculty Institute for Biochemistry, University of Tuebingen, Tuebingen, Germany; Institute of Pathology, University of Bonn, Bonn, Germany; Women ́s Hospital, University of Tuebingen, Tuebingen, Germany, German Cancer Consortium (DKTK) and German Cancer Research Center, Heidelberg, Germany * equal contribution (Petra Bareiss and Anna Paczulla have contributed equally and share first authorship)
منابع مشابه
SOX2 expression associates with stem cell state in human ovarian carcinoma.
The SRY-related HMG-box family of transcription factors member SOX2 regulates stemness and pluripotency in embryonic stem cells and plays important roles during early embryogenesis. More recently, SOX2 expression was documented in several tumor types including ovarian carcinoma, suggesting an involvement of SOX2 in regulation of cancer stem cells (CSC). Intriguingly, however, studies exploring ...
متن کاملTumor and Stem Cell Biology SOX2 Expression Associates with Stem Cell State in Human Ovarian Carcinoma
The SRY-related HMG-box family of transcription factors member SOX2 regulates stemness and pluripotency in embryonic stem cells and plays important roles during early embryogenesis. More recently, SOX2 expression was documented in several tumor types including ovarian carcinoma, suggesting an involvement of SOX2 in regulation of cancer stemcells (CSC). Intriguingly, however, studies exploring t...
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Objective(s): In some previous studies, the extract of embryonic carcinoma cells (ECCs) and embryonic stem cells (ESCs) have been used to reprogram somatic cells to more dedifferentiated state. The aim of this study was to investigate the effect of mouse ESCs extract on the expression of some pluripotency markers in human adipose tissue-derived stem cells (ADSCs). Materials and Methods: Human A...
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Ovarian cancer is the leading cause of death among gynecologic cancers and is the fifth leading cause of all cancer-related deaths among women. The development of novel molecular targets is therefore important to many patients. Recently, the SRY-related transcription factor SOX2 has been widely reported to be involved in multiple pathophysiological diseases, including maintenance of stem cell c...
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Hypoxia and NOTCH signaling have been reported to be associated with the self-renewal and drug resistance of cancer stem cells (CSCs). However, the molecular mechanisms by which hypoxia and NOTCH signaling stimulate the self-renewal and drug resistance of ovarian CSCs are poorly understood. In the present study, we identified SOX2 as a key transcription factor for CSC-like characteristics in th...
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تاریخ انتشار 2013